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Neurological Relevance Preclinical evidence suggests broader neuroprotective potential: In traumatic brain injury models, SS-31 reduced mitochondrial swelling, neuronal loss, and neuroinflammation Aged mice treated with SS-31 showed significantly improved exercise tolerance, muscle strength, and mitochondrial efficiency Studies demonstrate protection against ischemic injury and enhanced cardiac output Phase 3 trials are ongoing for dry age-related macular degeneration and primary mitochondrial myopathy (Stealth BioTherapeutics pipeline) Implications for Brain Aging Mitochondrial dysfunction is a hallmark of brain aging and neurodegeneration

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The reduction in local IGF-I expression was accompanied by a 15-fold decrease in local IGFBP-5 mRNA expression in heart failure, compared with control subjects[63]

No, microneedling is not a good option for sagging skin

Activated charcoal (1 g/kg, max 50100 g) is given within 12 hours after ingestion if the patient is awake and can protect their own airway

B12 shots for weight loss are not a standalone treatment